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An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study
Fei Ma1, Heyong Huang, Xuefeng Ge
1Analysis and Testing Center, Jiangsu Key Laboratory of Biofunctional Materials, School of Geograph Science, Nanjing Normal University, Nanjing 210046, PR China.
Bioorganic & Medicinal Chemistry Letters
|February 16, 2013
Abstract:
The complex of Hypocrellin A with Al(3+) is prepared in water solution by a facile method. The water-solubility and stability of complexes are improved. Irradiation of Al(3+)-HA complex results in higher efficient generation of singlet oxygen ((1)O2) and photocleavage ability to CT DNA than HA. In vitro studies have illustrated that the Al(3+)-HA complex has anti-cancer activity.
