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Updated: May 14, 2026

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
Published on: April 21, 2022
[A study of the sialogogic effect of cevimeline gargle]
Chizuko Yoshikawa1, Yasushi Takamatsu, Kentaro Ogata
1Dept. of Nursing, Fukuoka University Faculty of Medicine.
Abstract:
The purpose of this study was to clarify the sialogogic effect iveness of cevimeline gargle. Sequential comparison tests were conducted on healthy adult males and females who received both cevimeline and a placebo. The effect was evaluated by measuring the amount of saliva using the Saxon test and Mucus, and by recording the subjects' own perceptions of oral mucosal moisture reported according to 4 levels. First, ten subjects' measurements were taken before gargling, as well as 5 minutes, 90 minutes and 3 hours after gargling. For the cevimeline treatment, the amount of saliva reached the maximum level within 5 minutes after gargling, and a significant salivary secreting effect(p<0. 05-p<0. 001)was observed up to 90 minutes after gargling. The degree of oral moisture also reached the maximum level within 5 minutes after gargling with cevimeline, and a significant moisture effect(p<0. 05-p<0. 001)persisted up to 3 hours after gargling. After safety profiles were determined to be acceptable, an additional 19 subjects entered the study and the same results were observed. The present data, indicating that cevimeline gargle increases the saliva in healthy individuals for at least 3 hours, will be useful in clinical trials of cevimeline gargle for patients with salivary secretion disorder.
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