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Abolished net output of lymphocytes from the spleen after immunization with Salmonella typhi H

G Sandberg1

  • 1Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.

International Archives of Allergy and Applied Immunology
|January 1, 1990
PubMed

Cell release from the spleen was studied by comparing the content of mono- and polynuclear leucocytes in splenic afferent and efferent blood. A difference in the content of mononuclear cells was registered in normal animals, indicating a release of such cells from the spleen. Immunization with Salmonella typhi H antigen reduced this veno-arterial difference and abolished it totally after 11 days. Normal values were obtained again 28 days after immunization. The results indicate that the antigen causes an altered relation between input and output of mononuclear cells, mainly lymphocytes.

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