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Categories of hypertension in the elderly and their 1-year evolution. The Three-City Study
Cécilia Cacciolati1, Olivier Hanon, Carole Dufouil
1INSERM, Neuroepidemiology, Bordeaux, France.
Insights
Elderly individuals with high blood pressure readings at home or in the office face an increased risk of developing hypertension within a year. Home blood pressure monitoring is crucial for identifying those at high risk, especially those untreated.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Hypertension Research
Background:
- White-coat hypertension (WCHT) and masked hypertension (MHT) are conditions where blood pressure readings differ between clinical and home settings.
- Understanding the long-term risks associated with these conditions in the elderly is crucial for effective management.
Purpose of the Study:
- To evaluate the 1-year risk of sustained hypertension in untreated elderly individuals with WCHT or MHT.
- To assess the 1-year risk of uncontrolled hypertension in treated elderly individuals with office or home uncontrolled hypertension (OUHT or HUHT).
Main Methods:
- A community-based cohort study of 1481 elderly individuals (≥73 years) was conducted.
- Blood pressure was measured using a consistent device, defining WCHT, MHT, OUHT, and HUHT based on office and home readings, with or without antihypertensive treatment.
- Sustained hypertension and uncontrolled hypertension were defined by consistent high readings in both settings, with or without treatment.
Main Results:
- 13% of participants with high office BP and 26% with high home BP developed sustained or uncontrolled hypertension within 1 year.
- Individuals with high home BP had a seven-fold increased risk (OR = 6.8) compared to those with normal readings in both settings.
- Untreated individuals, particularly those with MHT, exhibited significantly higher risks (OR(MHT) = 16.8).
Conclusions:
- Elderly individuals with elevated office or home blood pressure readings face a heightened risk of developing hypertension within one year.
- The risk is substantially elevated in untreated individuals, especially those with masked hypertension.
- These findings underscore the importance of home blood pressure monitoring for early detection and management in the elderly population.
Objective:
To assess the 1-year risk of developing sustained hypertension in untreated elderly with white-coat hypertension (WCHT) or masked hypertension (MHT), and the 1-year risk of developing uncontrolled hypertension in treated elderly with office or home uncontrolled hypertension (OUHT or HUHT).
Methods:
We studied the 1-year risk of developing sustained or uncontrolled hypertension in a community-based cohort of 1481 individuals aged at least 73 years. The same BP device was used throughout the entire study. WCHT was defined as high blood pressure (BP) at office and normal home BP without antihypertensive intake, OUHT as high office BP and normal home BP with antihypertensive intake, MHT as high BP at home and normal office BP without antihypertensive intake, and HUHT as high home BP and normal office BP with antihypertensive intake. Sustained hypertension was defined as high office and home BP without antihypertensive intake and uncontrolled hypertension as high office and home BP with antihypertensive intake.
Results:
Sustained or uncontrolled hypertension at 1 year was diagnosed in 13% of participants with high office BP and in 26% of those with high home BP. Compared to participants with normal office and home BP, risk of sustained/uncontrolled hypertension was increased about three-fold in individuals with high office BP [OR = 2.9; 95% confidence interval (CI) = 1.5-5.5; P = 0.002] and about seven-fold in those with high home BP (OR = 6.8; 95% CI = 3.8-12.2; P < 0.0001). These risks were higher in individuals not treated by antihypertensive (OR(WCHT) = 4.3, P = 0.03; OR(MHT) = 16.8, P < 0.0001).
Conclusion:
In this community-based study, elderly individuals with high office or home BP had an increased risk of hypertension 1 year later. This risk was higher among individuals not treated by antihypertensive and particularly in those with MHT. As these high-risk individuals would be otherwise undetected our results strongly support the large use of home blood pressure measurement in the elderly.
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