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Updated: May 14, 2026
Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
Published on: February 21, 2015
Applications of array-CGH for lung cancer
Kenneth J Craddock1, Wan L Lam, Ming-Sound Tsao
1Department of Pathology, Toronto General Hospital University Health Network, Toronto, ON, Canada. ken.craddock@utoronto.ca
Abstract:
This chapter summarizes the current knowledge on gene copy number changes found in lung tumors, and their application in the diagnosis, prognostication, and prediction of response to chemotherapy. Examples of the identification of specific "driver" oncogenes within amplified DNA segments are described. A model of how array-CGH could be integrated clinically into the routine workup of lung cancers in clinical laboratory is proposed.
