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Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome

Mi Lim Chung1, Han Wok Yoo, Ki-Soo Kim

  • 1Department of Pediatrics, College of Medicine, Inje University, Haeundae Paik Hospital, Busan, Seoul, Cheonju.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|February 16, 2013
PubMed

Insights

Thyroid dysfunction is common in preterm infants. Persistent high thyroid-stimulating hormone (TSH) levels can negatively impact neurodevelopment, while other dysfunctions typically do not.

Area of Science:

  • Neonatal endocrinology
  • Pediatric neurodevelopment

Background:

  • Thyroid dysfunction is prevalent in preterm infants.
  • It is linked to neurodevelopmental impairments.

Purpose of the Study:

  • Determine the incidence and course of thyroid dysfunction in premature infants.
  • Assess the impact of these dysfunctions on neurodevelopmental outcomes.

Main Methods:

  • 177 premature infants (<34 weeks or <1500g) were enrolled.
  • Repeated thyroid function tests were performed.
  • Neurodevelopmental outcomes were assessed at 18 months corrected age.

Main Results:

  • Thyroid dysfunction occurred in 88 infants.
  • Hypothyroxinemia resolved spontaneously without affecting neurodevelopment.
  • Persistent hyperthyrotropinemia (high TSH) in 27 infants was associated with poor neurodevelopmental outcomes.

Conclusions:

  • Thyroid dysfunction is common in preterm infants.
  • Most thyroid issues, except persistent hyperthyrotropinemia, do not impact neurodevelopment.
  • Further research on thyroid hormone therapy for persistent hyperthyrotropinemia is warranted.
Abstract

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