Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Documentation in Long-Term and Home Healthcare Setting01:29

Documentation in Long-Term and Home Healthcare Setting

Documentation in long-term care facilities and home healthcare settings is crucial for ensuring continuous, coordinated, and comprehensive care for patients. Each setting has its specific documentation processes and tools:
Long-Term Care Facilities
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal associations between physical activity and preferred walking speed in community-dwelling older adults: a 4-year follow-up study.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·2026
Same author

Does sit-to-stand transition velocity vary across the day? Association with physical functioning and fatigability in community-dwelling older adults.

Innovation in aging·2026
Same author

Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.

Medicine and science in sports and exercise·2026
Same author

Association between relative free-living sit-to-stand transition thigh angular velocities and difficulties in mobility and daily functioning.

Aging clinical and experimental research·2026
Same author

Health-related resources and social support as enablers of digital device use among older Finns.

Journal of public health (Berlin, Germany)·2025
Same author

Use it or lose it: a four-year follow-up assessing whether physical activity near one's capacity reduces the risk of functional decline among older adults.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·2025

Related Experiment Video

Updated: May 14, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Promoting mobility in older people.

Taina Rantanen1

  • 1Department of Health Sciences and Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland. taina.rantanen@jyu.fi

Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi
|February 16, 2013
PubMed
Summary

Maintaining mobility is crucial for healthy aging and accessing community resources. Interventions should address physical function, sensory deficits, and environmental factors to support older adults

Keywords:
AgingEnvironmental barriersHealth promotionMotor activityMuscle strengthWalking

More Related Videos

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults
09:37

Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults

Published on: May 12, 2016

Related Experiment Videos

Last Updated: May 14, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults
09:37

Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults

Published on: May 12, 2016

Area of Science:

  • Gerontology
  • Public Health
  • Kinesiology

Background:

  • Out-of-home mobility is essential for accessing goods, services, and social participation, contributing to healthy aging.
  • Mobility assessment typically involves performance-based tests or self-reported difficulties, with declines most impacting complex tasks in older adults.
  • Age-related mobility decline can be exacerbated by individuals altering task performance to avoid difficulties, and is influenced by physiological systems.

Purpose of the Study:

  • To explore factors influencing mobility in older adults.
  • To identify interventions and strategies for preventing mobility decline.
  • To highlight the importance of both individual and environmental factors in maintaining mobility.

Main Methods:

  • Review of existing studies on mobility assessment and age-related decline.
  • Analysis of physiological underpinnings of mobility, including musculoskeletal, sensory, and neural systems.
  • Examination of the impact of individual interventions (e.g., strength training, physical activity counseling, sensory rehabilitation) and environmental factors.

Main Results:

  • Interventions targeting muscle strength, physical activity, and sensory function can improve mobility and prevent decline.
  • Sensory deficits like poor vision and hearing increase the risk of mobility decline and falls.
  • Environmental barriers and negative attitudes toward older adults' physical activity can accelerate mobility loss.

Conclusions:

  • Promoting mobility in older adults requires a multifaceted approach, including individual-focused interventions and community-level environmental modifications.
  • Addressing physiological factors, sensory impairments, and societal attitudes is key to supporting sustained out-of-home mobility.
  • Community initiatives should focus on enhancing physical accessibility and fostering positive perceptions of older adults' physical activity.