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Related Experiment Video

Updated: May 14, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

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Published on: March 9, 2018

EUCAST technical note on voriconazole and Aspergillus spp.

W W Hope¹, M Cuenca-Estrella, C Lass-Flörl

¹Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|February 19, 2013

Summary

The European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) established voriconazole breakpoints for Aspergillus species. These guidelines aid in interpreting antifungal susceptibility testing results for effective treatment.

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Area of Science:

Mycology
Clinical Microbiology
Pharmacology

Background:

Antifungal susceptibility testing is crucial for guiding therapy against Aspergillus infections.
Voriconazole is a key antifungal agent used to treat invasive aspergillosis.
Standardized breakpoints are needed for consistent interpretation of voriconazole's efficacy.

Purpose of the Study:

To present the established voriconazole breakpoints for Aspergillus species.
To provide a basis for clinical laboratories interpreting antifungal susceptibility data.
To inform treatment decisions for patients with Aspergillus infections.

Main Methods:

The breakpoints were determined by the EUCAST-AFST.
Methodology integrated epidemiological cut-off values.
Data synthesis included pharmacokinetic/pharmacodynamic parameters and clinical outcomes.

Main Results:

Defined voriconazole breakpoints for Aspergillus species are now available.
These breakpoints facilitate the classification of isolates as susceptible or resistant.
The established breakpoints support clinical decision-making.

Conclusions:

The EUCAST-AFST has successfully set voriconazole breakpoints against Aspergillus.
These breakpoints are essential for accurate interpretation of antifungal susceptibility tests.
Regular review of breakpoints will ensure continued relevance with emerging data.