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Updated: May 14, 2026
08:46
Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
Published on: September 16, 2014
Signal recognition particle: an essential protein-targeting machine
David Akopian1, Kuang Shen, Xin Zhang
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Annual Review of Biochemistry
|February 19, 2013
Summary
The signal recognition particle (SRP) and its receptor machinery ensure proteins reach their correct cellular membranes. Recent studies reveal their interactions and a GTPase cycle driving protein targeting with high accuracy.
Area of Science:
- Cell Biology
- Molecular Biology
- Protein Trafficking
Background:
- The signal recognition particle (SRP) and its receptor form a crucial cellular system for protein localization.
- This machinery is essential for directing newly synthesized proteins to membranes within the cell.
Purpose of the Study:
- To review recent mechanistic investigations of the SRP-SRP receptor system.
- To elucidate the interactions with cargo proteins and target membranes.
- To explain the novel GTPase cycle driving protein targeting.
Main Methods:
- High-resolution structural and biochemical analyses.
- Mechanistic investigations of protein-membrane interactions.
- GTPase cycle studies within the SRP-SRP receptor complex.
Main Results:
- Detailed understanding of how SRP and its receptor bind cargo proteins and target membranes.
- Elucidation of a novel GTPase cycle that powers protein targeting.
- Insights into mechanisms enhancing the fidelity of protein localization.
Conclusions:
- The SRP-SRP receptor system utilizes a sophisticated GTPase cycle for accurate protein targeting.
- Recent high-resolution studies have significantly advanced our understanding of this fundamental pathway.
- Further research is needed to address emerging questions in protein localization.
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