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Updated: May 14, 2026

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
Published on: October 4, 2017
New targets for glycosaminoglycans and glycosaminoglycans as novel targets
Bernd Gesslbauer1, Martina Theuer, Daniela Schweiger
1ProtAffin Biotechnologie AG, Reininghausstrasse 13a, 8020 Graz, Austria.
Abstract:
Biological functions of a variety of proteins are mediated via their interaction with glycosaminoglycans (GAGs). The structural diversity within the wide GAG landscape provides individual interaction sites for a multitude of proteins involved in several pathophysiological processes. This 'GAG angle' of such proteins as well as their specific GAG ligands give rise to novel therapeutic concepts for drug development. Current glycomic technologies to elucidate the glycan structure-function relationships, methods to investigate the selectivity and specificity of glycan-protein interactions and existing therapeutic approaches to interfere with GAG-protein interactions are discussed.
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