Androgen receptor may be responsible for gender disparity in gastric cancer

Men are at a higher risk of developing gastric cancer than women. However, the exact mechanisms responsible for the gender differences remain unclear. Recently, a number of epidemiological and genotyping studies have attributed the gender disparity in male-predominant cancers to the disruption of androgen receptor (AR) homeostasis. Moreover, previous data indicated that AR expression is an independent unfavorable prognostic factor in gastric cancer, suggesting that AR may play an important role in gastric carcinogenesis. In addition, mounting evidence suggests that AR is involved in many signaling pathways associated with gastric carcinogenesis. On the basis of the aforementioned evidence, we postulate that AR exhibits oncogenic properties in gastric cancer via several possible mechanisms, which may partly explain the higher prevalence of gastric cancer among males.