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Pancreatic atrophy and diabetes mellitus following blunt abdominal trauma

Mary J Edwards1, David F Crudo, Terri L Carlson

  • 1Department of Surgery, Tripler Army Medical Center, TAMC, HI 96859-5000, USA. mary.j.edwards@us.army.mil

Journal of Pediatric Surgery
|February 19, 2013
PubMed

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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