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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Importance of tuberculosis screening before inhibiting tumour necrosis factor-alpha therapy
A García-López1, C Burgueño-Montañés
1Servicio de Oftamología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain. albagarlo@hotmail.com
Introduction:
There has been an increase in the incidence of tuberculosis infection in recent years, due to the increasing use of drugs inhibiting tumour necrosis factor-alpha (anti-TNFα) in the treatment of inflammatory diseases.
Case Report:
We report the case of a male patient being treated with infliximab (anti-TNFα) who developed disseminated tuberculosis with ocular involvement.
Conclusion:
It is very important to conduct a proper screening to detect patients at risk for tuberculosis before starting treatment with these drugs. For this purpose, the QuantiFERON®-TB Gold in Tube (Interferon Gamma Release Assay, IGRA) is presented as an alternative screening test with high sensitivity and specificity.
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