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A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
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Dragon exploration system on marine sponge compounds interactions.

Sunil Sagar1, Mandeep Kaur, Aleksandar Radovanovic

  • 1King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research center, Thuwal, 23955-6900, Saudi Arabia. vladimir.bajic@kaust.edu.sa.

Journal of Cheminformatics
|February 19, 2013
PubMed
Summary
This summary is machine-generated.

Marine sponges offer valuable compounds for drug discovery. The Dragon Exploration System on Marine Sponge Compounds Interactions (DESMSCI) knowledge base aids researchers by integrating data and generating novel hypotheses for therapeutic development.

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Area of Science:

  • Marine natural products
  • Drug discovery
  • Bioinformatics

Background:

  • Natural products are crucial sources for novel therapeutic agents, with approximately 50% of recent drugs originating from them.
  • Marine natural products, particularly from sponges, represent a significant area for drug discovery.
  • Existing research highlights the importance of natural products in developing new medicines.

Purpose of the Study:

  • To develop an integrated knowledge base for marine sponge compounds and their interactions.
  • To support research on the utilization of marine sponge compounds in drug discovery.
  • To provide a comprehensive web resource for exploring marine sponge-derived chemical and biological data.

Main Methods:

  • Developed the Dragon Exploration System on Marine Sponge Compounds Interactions (DESMSCI) web resource.
  • Integrated data from PubMed and other databases on sponge compounds and their biological associations.
  • Employed text and data-mining approaches to compile information.
  • Included a hypothesis discovery module for generating novel associations.

Main Results:

  • DESMSCI provides information on associations between sponge compounds, human genes/proteins, diseases, and pathways.
  • The system enables visualization of relationships through textual, tabular, graphical, and network views.
  • A case study demonstrated a potential novel mode of action for variolins in Alzheimer's disease, derived from generated hypotheses.

Conclusions:

  • DESMSCI is the first comprehensive, publicly available resource for exploring marine sponge compound data.
  • The knowledge base facilitates research by integrating diverse biological and chemical information.
  • DESMSCI supports hypothesis generation and aids in discovering new therapeutic applications for marine compounds.