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Two-dimensional field-flow fractionation.

J C Giddings1

  • 1Department of Chemistry, University of Utah, Salt Lake City 84112.

Journal of Chromatography
|April 20, 1990
PubMed
Summary
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Two-dimensional field-flow fractionation (2D FFF) offers promising analytical capabilities by combining FFF with other separation techniques. This approach enhances separation selectivity and efficiency for complex samples.

Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Chromatography

Background:

  • Multidimensional field-flow fractionation (FFF) encompasses coupled separative stages or independent displacements within a planar channel.
  • Two-dimensional FFF, utilizing independent displacements with at least one FFF component, is particularly suitable for existing planar FFF channel geometries.
  • Adaptation requires broadening the channel and modifying inlets/outlets for dual-dimensional operation.

Purpose of the Study:

  • To explore the potential of two-dimensional FFF systems.
  • To categorize and discuss various configurations of 2D FFF.
  • To derive theoretical equations for trajectory deflection and analyze deflection selectivity.

Main Methods:

  • Discussion of four categories of 2D FFF systems: dual FFF, FFF-chromatography, FFF with field-induced displacement, and FFF with bulk/flow displacement.

Related Experiment Videos

  • Derivation of theoretical equations for trajectory deflection from the main flow axis (z).
  • Analysis of deflection selectivity based on component properties.

    • Main Results:

    • Identification of numerous potential 2D FFF system configurations.
    • Development of theoretical framework to predict and understand separation behavior in 2D FFF.
    • Demonstration of remarkably high deflection selectivity in several discussed examples.

    Conclusions:

    • Two-dimensional FFF presents a versatile platform for advanced separations.
    • The theoretical framework provides a basis for designing and optimizing 2D FFF systems.
    • High deflection selectivity indicates significant potential for resolving complex mixtures.