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Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based

Rehana Lovely1, Jobayer Hossain, Jonathen P Ramsey

  • 1Department of Cell Biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.

The Journal of Pediatrics
|February 19, 2013
PubMed

Insights

Elevated gamma-prime fibrinogen in obese children is linked to cardiovascular disease risks. A lifestyle intervention significantly reduced these levels, suggesting a potential therapeutic target.

Area of Science:

  • Cardiovascular disease research
  • Pediatric endocrinology
  • Hemostasis and thrombosis

Background:

  • Elevated plasma γ'-fibrinogen is associated with cardiovascular disease (CVD) and thrombosis risk in adults.
  • Obesity-related hyperfibrinogenemia is common in children, but the role of γ'-fibrinogen and its response to lifestyle interventions are not well understood.
  • Understanding these factors in pediatric populations is crucial for early CVD prevention.

Purpose of the Study:

  • To investigate whether elevated plasma γ'-fibrinogen increases CVD and thrombosis risk in children.
  • To examine the relationship between γ'-fibrinogen and other CVD risk factors in obese versus normal-weight children.
  • To assess the impact of a physical activity-based lifestyle intervention on γ'-fibrinogen levels.

Main Methods:

  • A randomized controlled trial involving a 3-month physical activity-based lifestyle intervention.
  • Measurement of γ'-fibrinogen concentration in 21 children (aged 14-18 years), divided into obese (>95th BMI percentile) and normal-weight (<85th BMI percentile) groups.
  • Assessment of relationships between γ'-fibrinogen, CVD risk factors (insulin resistance, inflammation), and body composition (DXA) before and after the intervention.

Main Results:

  • Obese children exhibited significantly higher γ'-fibrinogen concentrations compared to normal-weight children (P < .05).
  • γ'-fibrinogen levels were correlated with other CVD risk factors (adjusted R(2) = 0.9; P < .05), with insulin being the primary predictor.
  • The lifestyle intervention led to a significant reduction in γ'-fibrinogen concentration (P < .05).

Conclusions:

  • Obese, insulin-resistant children have elevated γ'-fibrinogen compared to lean controls.
  • A significant association exists between γ'-fibrinogen and other cardiovascular risk factors in this pediatric cohort.
  • Physical activity-based lifestyle interventions can effectively reduce γ'-fibrinogen levels in obese children.
Abstract

Keywords:
BMIBSABody mass indexBovine serum albuminC-reactive proteinCRPCVDCardiovascular diseaseDEXADual-energy X-ray absorptiometryHOMA-IRHomeostasis model of assessment–insulin resistanceILInterleukinPBSPhosphate-buffered saline

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