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Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity
Yvonne E Chiu1, Peter L Havens, Dawn H Siegel
1Department of Dermatology, Division of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ychiu@mcw.edu
Journal of the American Academy of Dermatology
|February 19, 2013
Summary
This study found no significant link between vitamin D levels and atopic dermatitis (AD) severity in children. Vitamin D deficiency was common, but did not correlate with AD symptoms.
Area of Science:
- Dermatology
- Pediatrics
- Endocrinology
Background:
- Atopic dermatitis (AD) is a common inflammatory skin condition in children.
- Previous research suggested a potential inverse correlation between vitamin D levels and AD severity.
Purpose of the Study:
- To investigate the statistical relationship between serum 25-hydroxyvitamin D concentration and the severity of atopic dermatitis in pediatric patients.
- To determine if vitamin D status is a significant factor in AD severity.
Main Methods:
- A cross-sectional study involving 94 pediatric patients (1-18 years) diagnosed with atopic dermatitis.
- Objective measurement of atopic dermatitis severity using the Severity Scoring of Atopic Dermatitis (SCORAD) index.
- Measurement of serum 25-hydroxyvitamin D concentrations and statistical analysis using univariate and multivariable models.
Main Results:
- Vitamin D deficiency (<20 ng/mL) was observed in 39% of subjects, insufficiency (21-29 ng/mL) in 35%, and sufficiency (≥30 ng/mL) in 26%.
- No statistically significant correlation was found between serum 25-hydroxyvitamin D concentration and SCORAD scores (r = -0.001; P = .99).
- Lower vitamin D levels were significantly associated with older age (≥3 years), Black race, and the winter season.
Conclusions:
- Serum 25-hydroxyvitamin D concentration is not significantly correlated with atopic dermatitis severity in the pediatric population studied.
- Limitations include uncontrolled factors like sunlight exposure, dietary vitamin D intake, and AD treatments, as well as a single time-point measurement.
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