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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...

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Correction: Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology.

The Journal of experimental medicine·2026
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A co-evolutionary perspective on humans and <i>Mycobacterium tuberculosis</i> in the era of systems biology.

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Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology.

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Elevated Plasma Matrix Metalloproteinases Are Associated With Mycobacterium tuberculosis Bloodstream Infection and Mortality in Human Immunodeficiency Virus-Associated Tuberculosis.

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Myeloid cell expression of CD200R is modulated in active TB disease and regulates <i>Mycobacterium tuberculosis</i> infection in a biomimetic model.

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Related Experiment Video

Updated: May 14, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Tuberculosis: time for a new perspective?

Paul T Elkington1

  • 1Clinical and Experimental Sciences, University of Southampton, Mailpoint 811, Southampton General Hospital, Southampton SO16 1YD, UK. p.elkington@soton.ac.uk

The Journal of Infection
|February 19, 2013
PubMed
Summary

Preventing Mycobacterium tuberculosis (Mtb) transmission requires new strategies beyond long-term vaccine trials. This perspective explores alternative, faster approaches to interrupt Mtb

Area of Science:

  • * Infectious Disease Research
  • * Vaccinology
  • * Public Health

Background:

  • * Mycobacterium tuberculosis (Mtb) transmission remains a significant global health challenge.
  • * Current pre-exposure vaccination strategies require extensive follow-up periods (25 years) to assess efficacy.
  • * Existing vaccines like BCG may not prevent adult pulmonary tuberculosis or could inadvertently aid Mtb dissemination.

Purpose of the Study:

  • * To discuss alternative strategies for interrupting the Mycobacterium tuberculosis life cycle.
  • * To explore approaches that can be implemented within a shorter timeframe compared to traditional vaccine development.
  • * To offer a personal perspective on novel tuberculosis control methods.

Main Methods:

  • * This is a personal perspective piece, not an experimental study.

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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

Related Experiment Videos

Last Updated: May 14, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

  • * Discussion of alternative strategies based on current understanding of Mtb transmission.
  • * Review of potential interventions for tuberculosis control.

    • Main Results:

    • * No experimental results are presented.
    • * Highlights the limitations of long-term vaccine efficacy studies.
    • * Emphasizes the need for rapid implementation of new control strategies.

    Conclusions:

    • * Traditional vaccine development timelines are insufficient for immediate Mtb control.
    • * Alternative strategies are necessary to rapidly interrupt Mycobacterium tuberculosis transmission.
    • * Exploring novel, shorter-term interventions is crucial for public health impact.