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Related Experiment Videos

Pulmonary function in the elderly: response to theophylline bronchodilation.

M H Chandler1, G D Clifton, N K Burki

  • 1Drug Product Evaluation Unit, University of Kentucky College of Pharmacy, Lexington.

Journal of Clinical Pharmacology
|April 1, 1990
PubMed
Summary

Elderly asthmatic individuals showed a reduced bronchodilator response to theophylline compared to younger adults. Further research is needed to determine if age or airway obstruction severity causes this difference in theophylline response.

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Area of Science:

  • Pharmacology
  • Gerontology
  • Pulmonology

Background:

  • Theophylline is a bronchodilator used for asthma management.
  • Elderly individuals may respond differently to medications due to age-related physiological changes.

Purpose of the Study:

  • To compare the pharmacologic response to theophylline in elderly versus young asthmatic individuals.
  • To investigate the relationship between theophylline plasma concentrations and pulmonary airway responses in different age groups.

Main Methods:

  • Ten young and ten elderly male asthmatic volunteers participated.
  • Intravenous aminophylline was administered to achieve incremental theophylline plasma concentrations (0-20 mcg/mL).
  • Pulmonary airway responses and heart rate changes were monitored.

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Main Results:

  • Elderly subjects had lower baseline pulmonary function, indicating more severe airway obstruction.
  • The elderly group showed a significantly lower absolute change in bronchodilator response to theophylline compared to the young group (P < .05).
  • Heart rate increased with theophylline concentration, with no significant difference between age groups.

Conclusions:

  • Elderly asthmatic individuals exhibit a diminished bronchodilator effect from theophylline.
  • The observed difference may be attributed to age or the severity of underlying airway obstruction.
  • Further studies are required to elucidate the specific factors influencing theophylline efficacy in the elderly.