Stability studies of ascorbic acid 2-glucoside in cosmetic lotion using surface response methodology

Area of Science:

• Cosmetic Science
• Biochemistry
• Chemical Engineering

Background:

• Ascorbic acid 2-glucoside (AA-2G) is a key ingredient in cosmetic formulations like creams and lotions.
• The stability of AA-2G is critical for maintaining its bio-functionality in cosmetic products.
• Temperature fluctuations and pH variations can lead to the degradation of AA-2G.

Purpose of the Study:

• To investigate the impact of temperature and pH on the stability of Ascorbic acid 2-glucoside (AA-2G).
• To determine the optimal conditions for maximizing AA-2G stability in cosmetic applications.
• To evaluate the antioxidative properties of AA-2G.

Main Methods:

• Response surface methodology (RSM) was employed to analyze the effects of temperature and pH.
• Stability of AA-2G was assessed under varying temperature and pH conditions.
• Antioxidative activities, including DPPH and ABTS free radical scavenging, metal chelating activity, and reducing ability, were measured.

Main Results:

• The optimal conditions for retaining AA-2G with the highest stability were identified as 55.3°C and pH 6.4.
• AA-2G demonstrated significant DPPH and ABTS free radical scavenging activities.
• AA-2G exhibited notable metal chelating activity and reducing ability.

Conclusions:

• Ascorbic acid 2-glucoside (AA-2G) exhibits good stability under specific temperature and pH conditions.
• AA-2G possesses significant antioxidative properties, making it a valuable active ingredient.
• The findings support the use of AA-2G in cosmetic products for enhanced efficacy and shelf-life.