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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Comprehensive embryo testing. Experts' opinions regarding future directions: an expert panel study on comprehensive
Kristien Hens1, Wybo J Dondorp, Joep P M Geraedts
1Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Maastricht University, PO Box 616, 6200 Maastricht, The Netherlands. k.hens@maastrichtuniversity.nl
Human Reproduction (Oxford, England)
|February 19, 2013
Summary
Comprehensive embryo testing, including whole-genome sequencing, is expected to impact IVF/PGD practices. Ethical reflection is crucial to address biological limitations and the interpretation of genetic variations in future embryo selection.
Area of Science:
- Reproductive Medicine
- Genetics
- Bioethics
Background:
- Comprehensive embryo testing using microarrays and whole-genome sequencing is emerging in preimplantation genetic diagnosis (PGD) and screening (PGS).
- Current research and ethical discussions primarily focus on existing PGD/PGS methods, neglecting the impact of comprehensive techniques.
- There is a need for empirical research and systematic reflection on the implications of advanced embryo testing technologies.
Purpose of the Study:
- To explore the future direction of comprehensive embryo testing as envisioned by experts in the field.
- To understand the potential impact and ethical considerations of advanced genetic screening in assisted reproductive technologies.
Main Methods:
- An expert panel was convened with seven pioneers in preimplantation genetic diagnosis (PGD).
- The panel included experts from Belgium, the Netherlands, Germany, and the UK, and was conducted in October 2011.
- The study aimed to gather insights into the future of comprehensive embryo testing.
Main Results:
- Experts anticipate the integration of comprehensive techniques into PGD and PGS, moving beyond single-gene testing or aneuploidy screening.
- This shift necessitates a broader ethical framework, considering a wider range of genetic criteria for embryo selection.
- Comprehensive preconception screening is expected to precede embryo testing, allowing for combined genetic analyses.
Conclusions:
- Comprehensive embryo testing presents significant biological and technical challenges, alongside uncertainties in interpreting genetic variations.
- The evolving landscape of embryo testing requires timely ethical reflection and empirical research, particularly concerning patient perspectives.
- Further studies are needed to gauge the views of infertile couples on embryo screening beyond aneuploidy.
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