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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Related Experiment Video

Updated: May 14, 2026

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

The case for lower extremity allotransplantation.

Matthew J Carty1, Ronald Zuker, Pedro Cavadas

  • 1Boston, Mass.; Toronto, Ontario, Canada; and Valencia, Spain From the Division of Plastic Surgery, Brigham and Women's Hospital; the Division of Plastic Surgery, Sick Kids Hospital; and Clinica Cavadas.

Plastic and Reconstructive Surgery
|February 19, 2013
PubMed
Summary

Lower extremity allotransplantation shows promise for amputees, building on successful upper limb transplants. Renewed consideration is advocated for this restorative therapy.

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Related Experiment Videos

Last Updated: May 14, 2026

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
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Published on: June 13, 2025

Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
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Published on: July 18, 2025

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Area of Science:

  • Regenerative Medicine
  • Transplantation Surgery
  • Orthopedic Surgery

Background:

  • Vascularized composite allotransplantation (VCA) has demonstrated success in various body sites over 20 years.
  • VCA for lower extremity amputees remains underutilized despite its potential benefits.

Purpose of the Study:

  • To review the potential benefits of lower limb allotransplantation.
  • To discuss the controversies surrounding this reconstructive treatment.

Main Methods:

  • Literature review of upper and lower extremity transplant outcomes.
  • Analysis of existing evidence for lower limb allotransplantation.

Main Results:

  • Evidence from upper and lower extremity transplants suggests lower limb allotransplantation is a viable option.
  • The procedure may offer significant restorative benefits for amputees.

Conclusions:

  • Lower extremity allotransplantation is a reasonable consideration for treating lower limb amputees.
  • Further investigation and clinical trials are warranted to fully embrace this therapeutic modality.