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Updated: May 14, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Obesity and its impact on transplantation and alloimmunity
Timm Heinbokel1, Bernhard Floerchinger, Andreas Schmiderer
1Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abstract:
Obesity has become an increasing problem in healthcare worldwide with far-reaching consequences. More obese patients with irreversible end-stage organ failure undergo organ transplantation, and organs from obese donors are more frequently used. A growing body of evidence suggests more frequent postoperative complications and inferior patient and graft survival linked to obesity. More recently, adipose tissue has been linked to chronic inflammatory processes potentially impacting alloimmune responses and graft quality.
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