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Dyslipidaemia in chronic kidney disease in Nepalese population

B Poudel1, B K Yadav, B Jha

  • 1Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal. bibekclb@yahoo.com

Mymensingh Medical Journal : MMJ
|February 19, 2013
PubMed

Insights

Patients with chronic kidney disease (CKD) have higher rates of dyslipidemia, a condition affecting blood lipid levels. This increased prevalence of dyslipidemia, including high cholesterol and triglycerides, is also evident in early stages of CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Patients with chronic kidney disease (CKD) face elevated risks for cardiovascular disease (CVD).
  • Dyslipidemia is a significant risk factor contributing to CVD development in CKD patients.
  • Understanding the prevalence of dyslipidemia across CKD stages is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the prevalence and patterns of dyslipidemia in patients with varying stages of chronic kidney disease (CKD).
  • To compare lipid profiles between CKD patients and healthy non-CKD controls.

Main Methods:

  • A hospital-based, cross-sectional study involving 163 CKD patients and 163 healthy controls.
  • CKD classification followed National Kidney Foundation guidelines.
  • Fasting lipid profiles (total cholesterol, HDL-C, LDL-C, TG) were analyzed.

Main Results:

  • Significant differences in mean lipid levels were observed between CKD stages and controls (p<0.05).
  • Higher prevalence of hypercholesterolemia (33.75% vs 21.47%), low HDL-C (32.5% vs 17.18%), and hypertriglyceridemia (35.58% vs 19.01%) in CKD patients.
  • Elevated LDL-C was also noted in CKD cases (38.03% vs 33.13%).

Conclusions:

  • Chronic kidney disease is associated with a significantly higher prevalence of dyslipidemia compared to the general population.
  • Dyslipidemia is present even in the early stages of CKD, highlighting the need for early intervention.
  • These findings underscore the importance of managing lipid profiles in CKD patients to mitigate cardiovascular risks.

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