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Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer

R Ranjha1, J Paul

  • 1School of Life Sciences, Jawharlal Nehru University, New Delhi, India.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|February 19, 2013
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are crucial in inflammatory diseases and their progression to cancer. Targeting these small RNAs offers therapeutic potential and early cancer detection biomarkers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology
  • Immunology

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNA molecules regulating gene expression post-transcriptionally.
  • Altered miRNA expression is implicated in the pathogenesis of various inflammatory diseases.
  • miRNAs play a significant role in maintaining cellular homeostasis and controlling gene expression.

Purpose of the Study:

  • To review the involvement of miRNAs in diverse inflammatory conditions.
  • To investigate the role of miRNAs in the transition of inflammatory diseases to cancer.
  • To explore the potential of miRNAs as therapeutic targets and diagnostic biomarkers.

Main Methods:

  • Systematic literature search conducted using the Pubmed database.
  • Studies focused on miRNA research in inflammatory diseases and cancer progression were included.
  • Analysis of existing research on miRNA's role in disease pathogenesis.

Main Results:

  • Significant evidence highlights the critical role of miRNAs in inflammatory diseases.
  • Specific miRNAs are involved in common inflammatory pathways, suggesting a link to cancer development.
  • miRNA expression profiles are altered in inflammatory diseases, impacting disease pathogenesis.

Conclusions:

  • miRNAs are integral to inflammatory processes and cancer development.
  • Future research should focus on therapeutic applications of miRNAs to target inflammation.
  • miRNAs hold promise as biomarkers for early cancer detection in inflammatory disease patients.

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