Complications of gamma knife neurosurgery and their appropriate management

There are four main risks with Gamma Knife neurosurgery. Firstly, there are direct complications that would not have arisen if the patient had not undergone the specific treatment under consideration. For radiosurgery, the direct complications are radiation-induced damage to the tissues, which may be temporary or permanent. They may be expressed clinically or be clinically silent. In addition, there are complications that are specific to certain diseases and their locations, such as pituitary failure following treatment of pituitary adenomas and deafness, facial palsy, or trigeminal deficit following the treatment of vestibular schwannomas. Second, there are indirect or management-related complications arising from delayed control of the disease process, such as a re-bleed after treatment of a vascular lesion before its occlusion. Third, there is the risk of induction of neoplasia from irradiation of normal tissue or tumor. These are separate processes. An example of the first would be induction of a glioma after treatment of a vascular malformation. An example of the second would be induction of malignant change in a benign vestibular schwannoma. Finally, there is treatment failure, where tumors continue to grow after treatment or vascular malformations fail to occlude.