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Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes
Lichen Yin1, Ziyuan Song, Kyung Hoon Kim
1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, IL 61801, USA.
Abstract:
Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.
