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Gout, hyperuricaemia, sleep apnoea-hypopnoea syndrome and vascular risk

Miguel Cantalejo Moreira1, Raúl María Veiga Cabello, Vanesa García Díaz

  • 1Unidad de Reumatología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain. mcantalejo.hflr@salud.madrid.org

Rheumatology (Oxford, England)
|February 19, 2013
PubMed

Insights

Patients with gout and hyperuricaemia and suspected sleep apnoea-hypopnoea syndrome (SAHS) show higher rates of cardiovascular risks and atherothrombosis. These individuals also present with more severe SAHS compared to osteoarthritis patients.

Area of Science:

  • Rheumatology
  • Sleep Medicine
  • Cardiology

Background:

  • Gout and hyperuricaemia are associated with cardiovascular (CV) and atherothrombotic risks.
  • Sleep apnoea-hypopnoea syndrome (SAHS) is increasingly recognized as a comorbidity impacting CV health.
  • The relationship between gout, hyperuricaemia, SAHS, and CV outcomes requires further investigation.

Purpose of the Study:

  • To evaluate cardiovascular and atherothrombosis risk factors in patients with gout and hyperuricaemia suspected of having SAHS.
  • To compare these risk factors against a control group of patients with osteoarthritis (OA) and confirmed SAHS.

Main Methods:

  • Clinical data on CV risk factors and atherothrombosis were collected from patients with gout and hyperuricaemia.
  • Polysomnography was used to confirm SAHS diagnosis, measuring the apnoea-hypopnoea index (AHI) and oxygen saturation (SaO2).
  • A control group of OA patients with confirmed SAHS was included for comparison.

Main Results:

  • Gout patients (77.8%) exhibited higher prevalence of CV risk factors and atherothrombosis (46.3%) compared to OA patients (66.7% and 0%, respectively).
  • SAHS was confirmed in 88.9% of gout patients, with a higher proportion experiencing moderate to severe forms.
  • Lower SaO2 levels were observed in the gout group (90.18%) versus the OA group (91.26%).

Conclusions:

  • A significant proportion of gout and hyperuricaemia patients with suspected SAHS were confirmed to have the condition.
  • Gout patients demonstrated a greater burden of CV risk factors, atherothrombosis, and more severe SAHS compared to the OA control group.
  • These findings highlight the critical link between gout, hyperuricaemia, SAHS, and cardiovascular/atherothrombotic disease.
Abstract

Keywords:
atherothrombosiscardiovascular riskgoutsleep apnoea-hypopnoea syndromeuric acid

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