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Updated: May 14, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
The "click" reaction involving metal azides, metal alkynes, or both: an exploration into multimetal structures
Luis Casarrubios1, María C de la Torre, Miguel A Sierra
1Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, 28040 Madrid, Spain.
Abstract:
Cu(I) -catalyzed 1,3-cycloaddition of azides and alkynes (CuAAC) is one of the most powerful synthetic methodologies known. However, its use to prepare well-defined multimetallic structures is underdeveloped. Apart from the applications of this reaction to anchor different organometallic reagents to surfaces, polymers, and dendrimers, only isolated examples of CuAAC with metal-η(1) -alkyne and metal-azide complexes to prepare multimetal entities have been reported. This concept sketches the potential of these reactions not only to prepare "a la carte" multimetal 1,2,3-triazole derivatives, but also to discover new and unprecedented reactions.
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