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Published on: May 22, 2019
Poststroke dementia is associated with recurrent ischaemic stroke.
Gerli Sibolt1, Sami Curtze, Susanna Melkas
1Department of Neurology, Helsinki University Central Hospital, P.O. Box 340 (Haartmaninkatu 4), , Helsinki 00029 HUS, Finland. gerli.sibolt@hus.fi
Journal of Neurology, Neurosurgery, and Psychiatry
|February 19, 2013
Summary
Poststroke dementia significantly increases the risk of recurrent ischemic stroke. This finding highlights the importance of considering dementia when assessing prognosis after a stroke.
Area of Science:
- Neurology
- Cardiovascular Research
- Geriatrics
Background:
- Ischemic stroke is a leading cause of long-term disability.
- Poststroke dementia (PSD) is a common complication affecting stroke survivors.
- The long-term impact of PSD on stroke recurrence risk remains an area of investigation.
Purpose of the Study:
- To determine if poststroke dementia (PSD) diagnosed after an ischemic stroke predicts recurrent ischemic stroke.
- To evaluate the long-term prognosis of patients with and without PSD following an initial ischemic stroke.
Main Methods:
- A cohort of 486 ischemic stroke patients were followed for 12 years.
- Dementia was diagnosed using DSM-III criteria.
- Kaplan-Meier and Cox proportional hazards models were used to analyze the association between PSD and recurrent stroke risk.
Main Results:
- Patients with PSD experienced recurrent strokes significantly sooner than those without dementia (7.13 vs 9.41 years).
- Poststroke dementia was independently associated with a nearly doubled risk of recurrent ischemic stroke (adjusted HR 1.84).
- This association was consistent in both the overall cohort and patients experiencing their first-ever stroke.
Conclusions:
- Poststroke dementia is a significant predictor of recurrent ischemic stroke.
- The presence of PSD should be incorporated into prognostic assessments for stroke survivors.
- Further research into the mechanisms linking dementia and stroke recurrence is warranted.
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