Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2026

Isolation and Characterization of Single Cells from Zebrafish Embryos
09:25

Isolation and Characterization of Single Cells from Zebrafish Embryos

Published on: March 12, 2016

Two dynamin-2 genes are required for normal zebrafish development.

Elizabeth M Gibbs1, Ann E Davidson, Arden Trickey-Glassman

  • 1Department of Neurology, University of Michigan, Ann Arbor, Michigan, United States of America.

Plos One
|February 19, 2013
PubMed
Summary

Zebrafish dynamin-2 (DNM2) genes are essential for development. Studying these zebrafish DNM2 orthologs provides insights into human neuromuscular disorders like centronuclear myopathy and Charcot-Marie-Tooth disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes.

European journal of neurology·2025
Same author

Air pollution and disease progression in a University of Michigan amyotrophic lateral sclerosis cohort.

Environmental research·2025
Same author

Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.

Frontiers in immunology·2025
Same author

The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

ALSUntangled #81: Pyridostigmine (mestinon<sup>®</sup>).

Amyotrophic lateral sclerosis & frontotemporal degeneration·2025
Same author

Shared genes and pathways in dementia: Insights from genome-wide association studies.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Dynamin-2 (DNM2) is a GTPase crucial for endocytosis and cellular trafficking.
  • Mutations in human DNM2 are linked to centronuclear myopathy and Charcot-Marie-Tooth disease.
  • Zebrafish serve as a valuable model for studying neurological disorders.

Purpose of the Study:

  • To characterize the zebrafish dynamin-2 (dnm2 and dnm2-like) orthologs.
  • To investigate the role of zebrafish DNM2 in development.
  • To assess the potential of zebrafish as a model for DNM2-related human diseases.

Main Methods:

  • Gene and protein structure analysis of zebrafish dnm2 and dnm2-like.
  • Expression pattern analysis during zebrafish development and in adult tissues.

More Related Videos

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function
10:06

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

Published on: October 19, 2013

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing
08:39

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing

Published on: September 1, 2017

Related Experiment Videos

Last Updated: May 14, 2026

Isolation and Characterization of Single Cells from Zebrafish Embryos
09:25

Isolation and Characterization of Single Cells from Zebrafish Embryos

Published on: March 12, 2016

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function
10:06

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

Published on: October 19, 2013

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing
08:39

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing

Published on: September 1, 2017

  • Knockdown studies using morpholinos and rescue experiments with human DNM2 RNA.

    • Main Results:

    • Zebrafish dnm2 and dnm2-like genes show structural similarity to human DNM2.
    • Both genes are expressed throughout zebrafish development and in adult tissues.
    • Knockdown of dnm2 and dnm2-like caused significant developmental abnormalities, which were rescued by human DNM2 RNA.

    Conclusions:

    • Zebrafish dnm2 and dnm2-like are functional orthologs of human DNM2.
    • These genes are essential for normal zebrafish development.
    • The study validates zebrafish as a relevant model for understanding DNM2-related neuromuscular disorders.