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Hyperhomocysteinaemia and chronic venous ulcers

Stefano de Franciscis1, Giovambattista De Sarro, Paola Longo

  • 1Department of Medical and Surgical Science, School of Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.

International Wound Journal
|February 20, 2013
PubMed

Insights

Hyperhomocysteinemia (HHcy) is common in chronic venous ulcers (CVU). Folic acid therapy improved healing rates in patients with HHcy, suggesting a link between homocysteine levels and venous ulcer recovery.

Area of Science:

  • Vascular Medicine
  • Dermatology
  • Wound Healing Research

Background:

  • Chronic venous ulceration (CVU) is a significant complication of chronic venous disease affecting lower extremities.
  • Previous research suggests a potential link between thrombophilic factors, like hyperhomocysteinemia (HHcy), and the development of chronic venous ulcers.

Purpose of the Study:

  • To determine the prevalence of HHcy in patients diagnosed with venous leg ulcers.
  • To investigate the impact of folic acid therapy on the healing of chronic venous ulcers in patients with HHcy.

Main Methods:

  • Eighty-seven patients with venous leg ulcers were enrolled.
  • All patients received standard care (compression therapy ± surgery).
  • Patients with HHcy received folic acid (1.2 mg/day for 12 months), while controls did not. Wound healing was assessed using computerized planimetry.

Main Results:

  • The prevalence of HHcy among patients with chronic venous ulcers was found to be 62.06%.
  • A statistically significant higher healing rate (P < 0.05) was observed in the folic acid treatment group (78.75%) compared to the control group (63.33%).

Conclusions:

  • A significant association exists between hyperhomocysteinemia and chronic venous ulceration.
  • Folic acid therapy appears to accelerate wound healing in patients with HHcy and CVU, though underlying mechanisms require further investigation.

Keywords:
Chronic venous diseaseChronic venous ulcerationHyperhomocysteinaemiaThrombophiliaVenous leg ulcer

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