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Related Experiment Video

Updated: May 14, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

[Magnetic nanoparticles as tools for cell therapy].

Claire Wilhelm1, Florence Gazeau

  • 1Laboratoire Matière et Systèmes Complexes, CNRS – Université Paris Diderot, 75205 Paris Cedex 13, France. claire.wilhelm@univ-paris-diderot.fr

Biologie Aujourd'Hui
|February 20, 2013
PubMed
Summary

Labeling living cells with magnetic nanoparticles enables advanced biomedical applications. These magnetic cells can be tracked non-invasively using Magnetic Resonance Imaging (MRI) and manipulated for regenerative medicine, with a clear path to clinical use.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cell Biology

Context:

  • Living cells can be labeled with magnetic nanoparticles for diverse biomedical applications.
  • Magnetic nanoparticles confer magnetic properties to cells without adverse effects on proliferation or function.
  • The magnetic field acts as a remote stimulus to activate or monitor cell behavior.

Purpose:

  • To describe methods for making cells responsive to magnetic fields via nanoparticle internalization.
  • To demonstrate the use of Magnetic Resonance Imaging (MRI) for non-invasive in vivo cell tracking.
  • To provide examples of magnetic cell manipulation and their applications in regenerative medicine.

Summary:

  • Cells are safely internalized with superparamagnetic nanoparticles, rendering them responsive to magnetic fields.

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Last Updated: May 14, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

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  • Magnetic Resonance Imaging (MRI) enables non-invasive in vivo monitoring of cell migration, crucial for cell therapy assays.
  • Magnetic cell manipulation offers promising advancements for tissue engineering and cell-based therapies.

    • Impact:

    • Magnetic cell labeling and tracking via MRI provide a method of choice for monitoring cell fate in cell therapy.
    • Magnetic cell manipulation techniques are expected to significantly improve tissue engineering and cell-based therapies.
    • Clinical approval of iron-oxide nanoparticles as MRI contrast agents facilitates the translation of these magnetic methods to human clinics.