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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

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Thiazolidine-2,4-diones: progress towards multifarious applications.

Viral S Jain¹, Dhagash K Vora, C S Ramaa

¹Department of Pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Sector-8, CBD Belapur, Navi Mumbai 400614, Maharashtra, India.

Bioorganic & Medicinal Chemistry

|February 20, 2013

Summary

Thiazolidine-2,4-dione compounds show diverse therapeutic potential, including anti-diabetic and anti-cancer effects. This review details their pharmacological activities and structural modifications to guide new drug development.

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Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Area of Science:

Medicinal Chemistry
Pharmacology
Drug Discovery

Background:

Thiazolidine-2,4-dione derivatives exhibit significant biological activities, including anti-hyperglycemic, anti-cancer, and anti-inflammatory properties.
The nucleus serves as a crucial scaffold for developing novel therapeutic agents, with diverse substituents modulating its activity spectrum.

Purpose of the Study:

To consolidate recent advancements in thiazolidine-2,4-dione research.
To provide a comprehensive overview of pharmacological activities linked to substitution patterns and docking studies.
To aid medicinal chemists in structure-activity relationship (SAR) development for novel drug candidates.

Main Methods:

Literature review of thiazolidine-2,4-dione derivatives and their pharmacological profiles.
Analysis of structure-activity relationships based on substitution patterns.
Inclusion of molecular docking studies against relevant biological targets.

Main Results:

Compilation of diverse pharmacological activities associated with various thiazolidine-2,4-dione derivatives.
Correlation of specific structural modifications with enhanced biological effects.
Identification of key interactions through docking studies to inform drug design.

Conclusions:

Thiazolidine-2,4-diones are versatile scaffolds with broad therapeutic applications.
Understanding SAR and target interactions is crucial for designing potent and selective drug candidates.
This review facilitates the rational design of new thiazolidine-2,4-dione-based therapeutics.