Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Respiration and Gaseous Exchange01:20

Respiration and Gaseous Exchange

The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incorporating the concept of overtransfusion into hemovigilance monitoring: An expert-based definition and criteria from the International HIT-OVER Forum.

Transfusion·2024
Same author

Evaluating Osteoarthritis Management Programs: outcome domain recommendations from the OARSI Joint Effort Initiative.

Osteoarthritis and cartilage·2023
Same author

Use of local anesthesia for inguinal hernia repair has decreased over time in the VA system.

Hernia : the journal of hernias and abdominal wall surgery·2021
Same author

Influence of the tensile static preload dependency on the dynamic lifetime prediction for an HNBR elastomer.

Journal of the mechanical behavior of biomedical materials·2021
Same author

[Saddle thrombus in the region of the aortic bifurcation and critical limb ischaemia of the left leg associated with SARS-CoV-2 infection].

Gefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie·2021
Same author

The Effect of Dye and Pigment Concentrations on the Diameter of Melt-Electrospun Polylactic Acid Fibers.

Polymers·2020

Related Experiment Video

Updated: May 14, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Why hyperoxia matters during acute anemia.

P Lauscher1, V Mirakaj, K Koenig

  • 1Clinic of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Tübingen, Germany. patrick.lauscher@uni-tuebingen.de

Minerva Anestesiologica
|February 20, 2013
PubMed
Summary
This summary is machine-generated.

Hyperoxic ventilation significantly enhances oxygen delivery to tissues, even without hypoxemia. This method provides a highly available oxygen source, with theoretical benefits comparable to adding 3-7 g/dL of hemoglobin.

Related Experiment Videos

Last Updated: May 14, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Area of Science:

  • Physiology
  • Medical Science

Background:

  • Low plasma oxygen solubility traditionally limits hyperoxic ventilation's perceived value.
  • This study challenges the notion that hyperoxic ventilation is ineffective without hypoxemia.

Purpose of the Study:

  • To reevaluate the efficacy of hyperoxic ventilation in improving tissue oxygenation using mathematical modeling.
  • To quantify the theoretical benefit of hyperoxic ventilation in terms of hemoglobin equivalents.

Main Methods:

  • Mathematical modeling was employed to assess oxygen delivery.
  • Calculated the "hemoglobin equivalent" representing the additional hemoglobin needed for similar oxygen delivery.

Main Results:

  • Previous estimates of hyperoxic ventilation's efficacy were underestimated (1-2 g/dL Hb equivalent).
  • This study reveals a theoretical hemoglobin equivalent of 3-7 g/dL, dependent on physiological factors.

Conclusions:

  • Hyperoxic ventilation provides a readily usable oxygen source for tissues.
  • The tissue oxygenation efficacy of hyperoxic ventilation is likely underestimated in clinical practice.