Related Experiment Video

Updated: May 14, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Anesthetic management in pediatric patients with epidermolysis bullosa: a single center experience

I Van Den Heuvel1, M Boschin, M Langer

  • 1Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University hospital Muenster, Germany. vandenhe@uni-muenster.de

Minerva Anestesiologica
|February 20, 2013
PubMed

Insights

Deep sedation/analgesia is a safe and efficient anesthesia alternative for children with dystrophic epidermolysis bullosa (EB). This method reduces anesthesia time and complications compared to general anesthesia.

Area of Science:

  • Pediatric Anesthesiology
  • Dermatology
  • Genetic Disorders

Background:

  • Anesthesia in pediatric dystrophic epidermolysis bullosa (EB) poses challenges due to difficult airways and blistering risks.
  • General anesthesia and deep sedation/analgesia were compared for safety and efficiency in these patients.

Purpose of the Study:

  • To evaluate the safety and efficiency of deep sedation/analgesia versus general anesthesia in children with dystrophic EB.
  • To compare airway management, complications, and recovery times between the two anesthetic approaches.

Main Methods:

  • Retrospective study of 14 children undergoing 148 procedures.
  • Procedures were categorized by general anesthesia (79) or deep sedation/analgesia (67).
  • Data collected included airway management, complications, induction/awakening times, and recovery room stay.

Main Results:

  • No complications were observed in the sedated group, unlike the general anesthesia group which had intubation difficulties and airway management changes.
  • Induction time was significantly shorter with sedation (17 min) compared to general anesthesia (36 min) (P<0.001).
  • Recovery time was also shorter with sedation (6 min) versus general anesthesia (23 min) (P<0.001).

Conclusions:

  • Deep sedation/analgesia is a safe alternative for anesthesia in children with dystrophic EB.
  • Sedation/analgesia is more time-efficient than general anesthesia for procedures in this patient population.
Abstract

More Related Videos

Surgical Correction for Pediatric Epiblepharon and Trichiasis03:59

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Epistaxis01:30

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...