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Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Published on: January 7, 2019
Ketogenic diet
Radhika Dhamija1, Susan Eckert, Elaine Wirrell
1Division of Child and Adolescent Neurology, Mayo Clinic Children's Center, Rochester, MN, USA.
Summary
The ketogenic diet is effective for drug-resistant epilepsy in children and adults when surgery isn't an option. This review covers diet types, mechanisms, evidence, and practical application for neurological disorders.
Area of Science:
- Neurology
- Dietary Science
Background:
- Approximately one-third of epilepsy patients exhibit pharmacoresistance.
- The ketogenic diet offers a viable therapeutic option for a subset of these patients.
Purpose of the Study:
- To review ketogenic diet types, mechanisms, and efficacy in epilepsy.
- To provide guidance on diet initiation, maintenance, and side effect monitoring.
- To explore ketogenic diet applications in other neurological disorders.
Main Methods:
- Literature review of ketogenic diet research in epilepsy.
- Analysis of proposed mechanisms of action.
- Summary of clinical evidence in pediatric and adult populations.
- Discussion of practical implementation and monitoring strategies.
Main Results:
- The ketogenic diet demonstrates significant efficacy in managing both generalized and focal epilepsies, particularly when pharmacoresistant.
- Evidence supports its use in children and adults, especially when surgical intervention is not feasible.
- Emerging research suggests potential benefits in a wider spectrum of neurological conditions.
Conclusions:
- The ketogenic diet is a valuable, evidence-based therapeutic strategy for drug-resistant epilepsy.
- Early consideration of the ketogenic diet is recommended for suitable patients.
- Further research is warranted to explore its broader neurological applications.
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