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Related Concept Videos

Migration00:53

Migration

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.

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Related Experiment Video

Updated: May 14, 2026

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

Age-dependent regional changes in the rostral migratory stream.

Arie S Mobley1, Alex K Bryant, Marion B Richard

  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.

Neurobiology of Aging
|February 20, 2013
PubMed
Summary

Aging impacts the migration route of new olfactory bulb neurons but does not alter their final cell types or distribution. This suggests age-related olfactory deficits may stem from changes in the migration pathway, not neuron differentiation.

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Related Experiment Videos

Last Updated: May 14, 2026

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain
10:41

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

Published on: December 11, 2010

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
04:17

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Aging Research

Background:

  • The subventricular zone (SVZ) continuously generates interneurons for the olfactory bulb (OB) throughout life.
  • Neuroblasts migrate via the rostral migratory stream (RMS) to the OB, where they differentiate into granule and periglomerular (PG) cells.
  • Age-related decline in SVZ neurogenesis may contribute to olfactory deficits, but the impact on RMS and interneuron differentiation is unclear.

Purpose of the Study:

  • To investigate how aging affects the rostral migratory stream (RMS) and periglomerular (PG) cell subpopulations.
  • To examine age-related changes in neuroblast proliferation, migration, and clearance within the RMS.

Main Methods:

  • Analysis of RMS cytoarchitecture, neuroblast proliferation, and clearance in mice at 6, 12, 18, and 23 months of age.
  • Assessment of periglomerular (PG) cell subpopulations and their distribution across different age groups.

Main Results:

  • Aging alters the space occupied by new cells within the RMS and affects regional neuroblast proliferation.
  • Despite changes in RMS cellularity, the clearance of neuroblasts from the RMS remains stable with age.
  • Periglomerular (PG) cell subpopulations and their distribution within the olfactory bulb are maintained across the ages studied.

Conclusions:

  • While aging impacts neuroblast migration dynamics within the RMS, the differentiation and distribution of key interneuron types (PG cells) are preserved.
  • These findings suggest that age-related olfactory dysfunction may be linked to alterations in the migratory environment (RMS) rather than a failure in neuroblast differentiation.