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Related Concept Videos

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Phosphodiester Linkages01:01

Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...

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Related Experiment Video

Updated: May 14, 2026

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

The read-write Linked Data Web.

Tim Berners-Lee1, Kieron O'Hara

  • 1Computer Science and AI Laboratory, Massachusetts Institute of Technology, Vassar Street, Cambridge, MA 02139, USA.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|February 20, 2013
PubMed
Summary
This summary is machine-generated.

The future Web depends on developing the Linked Data Web, utilizing linked open data. This read-write approach is crucial for enhancing the Web's power and utility.

Related Experiment Videos

Last Updated: May 14, 2026

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

Area of Science:

  • Computer Science
  • Information Science

Background:

  • The evolution of the World Wide Web faces critical development challenges.
  • The current Web's utility can be significantly enhanced through advanced data integration.

Purpose of the Study:

  • To explore factors influencing the future development of the Web.
  • To advocate for the advancement of the Linked Data Web and its components.
  • To establish the Web as a read-write medium for data interaction.

Main Methods:

  • Discussion of key issues impacting Web development.
  • Analysis of the role of Linked Data and linked open data.
  • Conceptualization of a read-write Linked Data Web framework.

Main Results:

  • Identified critical factors that will shape the Web's future.
  • Highlighted the importance of Linked Data for Web utility.
  • Proposed a model for a read-write Linked Data Web.

Conclusions:

  • Continued development of the Linked Data Web is essential.
  • Linked open data is a key enabler for a more powerful Web.
  • Achieving a read-write Linked Data Web is a viable and important goal.