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Related Concept Videos

Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Contact-dependent Signaling01:19

Contact-dependent Signaling

Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: May 14, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

CCN proteins: A centralized communication network.

Bernard Perbal1

  • 1International CCN Society, Paris, France, bperbal@gmail.com.

Journal of Cell Communication and Signaling
|February 20, 2013
PubMed
Summary
This summary is machine-generated.

The CCN protein family, comprising six members (CCN1-6), acts in concert to coordinate signaling pathways. Understanding their collective roles is crucial for deciphering complex biological regulation.

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

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Last Updated: May 14, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
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Oligomerization Dynamics of Cell Surface Receptors in Living Cells by Total Internal Reflection Fluorescence Microscopy Combined with Number and Brightness Analysis
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Signaling
  • Protein Families

Background:

  • The CCN family includes six proteins (CCN1-6), originally known as CYR61, CTGF, NOV, and WISP-1-3.
  • These proteins share structural features but exhibit diverse biological functions.
  • Early predictions about CCN protein functions have largely been validated over time.

Purpose of the Study:

  • To critically review the progress in understanding CCN protein functions over the past decade.
  • To identify knowledge gaps and overlooked research avenues concerning CCN protein interactions.
  • To propose a unified view of the CCN family as a coordinated signaling network.

Main Methods:

  • Literature review and critical analysis of published data on CCN proteins.
  • Examination of structural similarities and functional diversities within the CCN family.
  • Synthesis of evidence supporting the coordinated action of CCN proteins.

Main Results:

  • Much of the current knowledge on CCN protein functions was predicted early in their discovery.
  • Overlooked data suggests the need to reconsider past findings.
  • CCN proteins likely function in concert, simultaneously or sequentially, to regulate biological processes.

Conclusions:

  • The CCN family acts as a cohesive unit, coordinating multiple signaling pathways.
  • Viewing the CCN family as a whole, rather than individual proteins, is essential for understanding their roles.
  • CCN proteins form a Centralized Communication Network, and deciphering their regulatory hierarchy is a key future challenge.