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Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor
M F Hibert1, R Hoffmann, R C Miller
1Merrell Dow Research Institute, Strasbourg, France.
Journal of Medicinal Chemistry
|June 1, 1990
Abstract:
A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model.