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Positive ProbeTec tests in fresh specimens from malignant musculoskeletal tumors: a case series
Chia-liang Ang1, Leon Siang-shen Foo, Shichao Sun
1Department of Orthopaedic Surgery, Singapore General Hospital, Singapore. med80199@yahoo.com
Objective:
To report a case series of patients with high-grade musculoskeletal sarcomas whose biopsies of fresh specimens yielded positive Becton Dickinson ProbeTec tests, in addition to confirming diagnoses of high-grade sarcomas.
Methods:
Fresh biopsies of high-grade musculoskeletal sarcomas were subjected to ProbeTec tests.
Results:
The biopsies of three Chinese patients aged 65, 49 and 78 years with high-grade musculoskeletal sarcomas had positive Becton Dickinson ProbeTec tests. These patients' overall clinical pictures were not consistent with active tuberculous infections, which suggested that the ProbeTec test results were false-positives. The reason for this is not known but it is postulated that there is homology between the primers used for the ProbeTec test and the molecular properties of high-grade sarcomas.
Conclusion:
With the increasing use of the ProbeTec test in clinical practice, fellow surgeons and pathologists are encouraged to be aware of this phenomenon.
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