Related Experiment Video

Updated: May 14, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Prevalence of childhood celiac disease and changes in infant feeding

Anneli Ivarsson1, Anna Myléus, Fredrik Norström

  • 1Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden. anneli.ivarsson@epiph.umu.se

Pediatrics
|February 20, 2013
PubMed

Insights

Introducing gluten gradually during breastfeeding may prevent celiac disease. This study found a lower prevalence in children born after an epidemic, linked to infant feeding practices.

Area of Science:

  • Pediatric Gastroenterology
  • Epidemiology
  • Immunology

Background:

  • Sweden observed an increase in pediatric celiac disease cases between 1984-1996.
  • Changes in infant feeding practices were suspected as a contributing factor.
  • The impact of infant feeding on celiac disease occurrence and presentation was unclear.

Purpose of the Study:

  • To compare the prevalence of celiac disease in two birth cohorts of 12-year-olds.
  • To investigate the association between infant feeding practices and celiac disease incidence.
  • To evaluate the effectiveness of current infant feeding recommendations.

Main Methods:

  • A two-phase cross-sectional screening study involving 13,279 children from two birth cohorts (1993 and 1997).
  • Serological markers were analyzed, with positive cases confirmed by small intestinal biopsy.
  • Infant feeding practices were collected via questionnaires, and prevalence ratios were calculated.

Main Results:

  • The overall prevalence of celiac disease was 29/1000 for the 1993 cohort and 22/1000 for the 1997 cohort.
  • Children born in 1997 had a significantly lower risk (PR=0.75, P=.01) compared to the 1993 cohort.
  • Differences in infant feeding, specifically gradual gluten introduction during breastfeeding, were noted between cohorts.

Conclusions:

  • A reduced celiac disease prevalence suggests potential for disease prevention strategies.
  • Current recommendations for gradual gluten introduction from 4 months, especially during breastfeeding, appear favorable.
  • Infant feeding practices play a significant role in celiac disease development.
Abstract

More Related Videos

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers07:18

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers

Published on: January 9, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...