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Hg(II)-mediated intramolecular cyclization reaction in aqueous media and its application as Hg(II) selective
Ananta Kumar Atta1, Seul-Bi Kim, Jungseok Heo
1Department of Chemistry, Inha University, 253 Yonghyundong, Namgu, Incheon 402-751, Republic of Korea.
Abstract:
The Hg(II)-specific intramolecular cyclization reaction of ethynyl phenols was carried out for the first time in semiaqueous media at ambient temperature. The reaction unit (ethynyl phenol) was coupled with a malononitrile derivative (signal unit), which afforded the chromogenic Hg(II) indicator 7. The reaction of the chromogenic Hg(II) indicator 7 was further optimized in DMSO/water (3:7, v/v) (10 mM PBS buffer, pH = 7.0). Compound 7 displays a color change from blue to pale yellow in the presence of Hg(II).
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