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Updated: May 14, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
Published on: August 23, 2022
An unusual case of trisomy 18 associated with paucity of bile ducts
Zelal Kahramaner1, Aydin Erdemir, Hese Cosar
1Department of Pediatrics, Division of Neonatology, Ministry of Health, Izmir Tepecik Research and Teaching Hospital, Turkey.
Abstract:
A case of neonatal cholestasis associated with Trisomy 18 (Edward's syndrome) is presented. A 3-day-old boy was referred to our clinic due to respiratory distress, elevated serum direct bilirubin levels, a systolic heart murmur, growth restriction and micrognathia. Liver biopsy and chromosomal analysis revealed paucity of intrahepatic bile ducts and Trisomy 18. Extrahepatic biliary atresia was reported in only a few patients with Trisomy 18. To our knowledge, we described for the first time a patient with Trisomy 18 and neonatal cholestasis associated with paucity of interlobular bile ducts.
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