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Related Experiment Videos

Augmentation cystoplasty utilizing de-epithelialized sigmoid colon: a preliminary study.

R C Motley1, B T Montgomery, P E Zollman

  • 1Department of Urology, Mayo Clinic, Rochester, Minnesota 55905.

The Journal of Urology
|June 1, 1990
PubMed
Summary

Bowel segments used for bladder augmentation can cause complications. Covering de-epithelialized intestinal grafts with transitional epithelium in sigmoidocystoplasty may reduce mucus and obstruction, but graft contracture remains a concern.

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Area of Science:

  • Urology
  • Gastroenterology
  • Tissue Engineering

Background:

  • Bowel segments for bladder augmentation can lead to metabolic issues and mucus-related obstruction.
  • Transitional epithelium coverage of de-epithelialized intestinal grafts is a potential strategy to mitigate these complications.

Purpose of the Study:

  • To evaluate the efficacy of establishing a transitional epithelium over de-epithelialized sigmoid grafts in preventing complications associated with bladder augmentation.

Main Methods:

  • Sigmoidocystoplasty was performed on 20 Holstein bull calves.
  • Experimental group (14 calves): sigmoid epithelium removed before augmentation.
  • Control group (6 calves): intact mucosa.
  • Cystectomies performed at 4, 6, 8, or 12 weeks.

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Main Results:

  • 91% of experimental calves showed near-complete epithelialization of de-epithelialized grafts.
  • All experimental animals had residual colonic mucosa or mucoceles.
  • 82% of experimental calves experienced >25% graft contracture.
  • Control animals developed wide-mouthed diverticula without contracture.

Conclusions:

  • While epithelialization occurred, residual mucosa and significant graft contracture were observed in experimental animals.
  • Sigmoid graft contracture remains a challenge in this bladder augmentation model.
  • Further research is needed to optimize techniques for preventing contracture and mucocele formation.