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Updated: May 14, 2026
10:40
Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
Published on: December 5, 2025
Adipokines in obesity.
Viviane de Oliveira Leal1, Denise Mafra
1Graduate Program in Medical Sciences, Faculdade de Nutrição, Federal Fluminense University (UFF), Niterói, Brazil. vivianeoleal@yahoo.com.br
Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 21, 2013
Summary
White adipose tissue releases adipokines, crucial signaling molecules. This review explores how obesity-specific adipokine profiles contribute to metabolic disorders like insulin resistance and inflammation.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Adipose Tissue Biology
Background:
- White adipose tissue functions as an endocrine organ, secreting bioactive polypeptides called adipokines.
- Obesity, characterized by excessive adipose tissue growth, may alter adipokine profiles.
- Adipokines are implicated in obesity-related conditions such as insulin resistance, inflammation, and cardiovascular risk.
Purpose of the Study:
- To review obesity-specific adipokine profiles.
- To elucidate the role of specific adipokines in obesity-related metabolic disorders.
Main Methods:
- Literature review of studies on adipokines and obesity.
- Analysis of research linking adipokine profiles to metabolic dysfunction.
Main Results:
- Obesity is associated with distinct changes in adipokine secretion.
- Specific adipokines play significant roles in mediating insulin resistance and inflammation in obesity.
- Altered adipokine signaling contributes to the pathogenesis of metabolic disorders.
Conclusions:
- Adipokines are key mediators in the development of obesity-related metabolic diseases.
- Understanding obesity-specific adipokine profiles is crucial for therapeutic strategies.
- Targeting adipokine pathways may offer novel treatments for metabolic disorders.
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