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Chalcones from the flowers of Coreopsis lanceolata and their in vitro antioxidative activity
Ya Fang Shang1, Sarangerel Oidovsambuu, Je-Seung Jeon
1Functional Food Center, KIST Gangneung Institute, Gangwon, Korea.
Abstract:
Three new chalcones, 3,2'-dihydroxy-4,3'-dimethoxychalcone-4'-glucoside (1), 4'-O-(2'''-O-caffeoyl)2',3',3,4-tetrahydroxychalcone (2), and 2',4',3-trihydroxy-3',4-dimethoxychalcone (3), along with five known phenolics, were isolated from Coreopsis lanceolata flowers. The structures of the new compounds were elucidated by extensive spectroscopic methods including NMR and MS. The three new chalcones showed a good in vitro HepG2 cell protecting effect against tert-butylhydroperoxide-induced oxidative stress.
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