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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.

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Updated: May 14, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

In brief: cell senescence.

Philip J Coates1

  • 1Tayside Tissue Bank, Level 5, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK. p.j.coates@dundee.ac.uk

The Journal of Pathology
|February 21, 2013
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a process limiting cancer, involves genetic and epigenetic changes. Harnessing senescence induction for cancer therapy requires new methods to identify therapeutic targets in tumors.

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Techniques to Induce and Quantify Cellular Senescence
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

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Last Updated: May 14, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

Area of Science:

  • Oncology
  • Cell Biology
  • Immunology

Background:

  • Cellular senescence is a fundamental biological process that acts as a crucial barrier against cancer development.
  • Understanding the genetic and epigenetic underpinnings of senescence is key to its therapeutic exploitation.
  • Senescence influences the tumor microenvironment and immune surveillance, impacting cancer progression.

Purpose of the Study:

  • To present the fundamental aspects of cellular senescence.
  • To explore the genetic and epigenetic factors driving senescence.
  • To discuss the potential of senescence induction as an anti-cancer therapeutic strategy.

Main Methods:

  • Review of current literature on cellular senescence.
  • Analysis of genetic and epigenetic events leading to the senescent phenotype.
  • Discussion of immune clearance and microenvironment alteration mechanisms.

Main Results:

  • Cellular senescence limits cancer development by restricting cell proliferation.
  • Senescence induction involves specific genetic and epigenetic alterations.
  • Senescence signals immune cells and modifies the tumor microenvironment.

Conclusions:

  • Cellular senescence is a vital anti-cancer mechanism.
  • Targeting senescence for cancer therapy holds promise.
  • Development of assays to identify senescence targets in individual tumors is crucial for therapeutic success.