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Related Concept Videos

Cell Diversity01:13

Cell Diversity

The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...

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Related Experiment Video

Updated: May 14, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Modeling cell heterogeneity: from single-cell variations to mixed cells.

Eric Batchelor1, Maricel G Kann, Teresa M Przytycka

  • 1Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894, USA. eric.batchelor@nih.gov

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
|February 21, 2013
PubMed
Summary

New single-cell technologies offer deep insights into cellular variation. This workshop unites researchers to model cell heterogeneity in diverse biological contexts like immunity and cancer.

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Related Experiment Videos

Last Updated: May 14, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

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Published on: October 25, 2018

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Published on: June 30, 2017

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Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

Published on: January 19, 2017

Area of Science:

  • Genomics and Molecular Biology
  • Systems Biology
  • Immunology

Background:

  • Single-cell gene expression analysis and genome sequencing reveal biological interactions at an unprecedented resolution.
  • Understanding cellular variation is crucial for accurately depicting cellular behavior across various biological contexts.

Framework:

  • Focus on identifying and modeling cell heterogeneity from diverse mechanisms.
  • Addresses sources of variation including cell-to-cell noise, cell-state transitions, and differentiation.

Implementation:

  • Workshop format to foster collaboration among researchers.
  • Discussion of computational and experimental approaches for heterogeneity analysis.

Implications:

  • Enhanced understanding of cellular heterogeneity in fundamental biology.
  • Improved insights into disease progression, immune responses, and cancer evolution.
  • Advancement of single-cell analysis methodologies for biological research.